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Patients must know that this drug, even if taken as suggested may lead to addiction, abuse, and misuse; instruct patients never to share their drug with Other folks and shield their drug from theft or misuse.
e., a better dose of the drug is required to generate the same impact which was once obtained in a lower dose).
Acetaminophen and codeine phosphate tablets must be prescribed only by healthcare pros who're knowledgeable about using opioids and the way to mitigate the affiliated threats.
Propulsive peristaltic waves within the colon are diminished, although tone might be amplified to the point of spasm, resulting in constipation. Other opioid-induced effects might consist of a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
The next adverse reactions connected to the usage of codeine were being identified in postmarketing studies. Simply because A few of these reactions had been documented voluntarily from the inhabitants of uncertain size, It's not generally probable to reliably estimate their frequency or establish a causal connection to drug exposure.
Neonatal get more info Opioid Withdrawal Syndrome Notify woman patients of reproductive prospective that utilization of acetaminophen and codeine phosphate tablets for click here an prolonged stretch of time through pregnancy can result click here in neonatal opioid withdrawal syndrome, which may be existence-threatening Otherwise acknowledged and dealt with (see PRECAUTIONS, Pregnancy).
Titrate the dose based mostly on the individual patient’s reaction for their Preliminary dose of acetaminophen and codeine phosphate tablets.
Sufferers really should understand this drug has likely severe Unintended effects such as adrenal insufficiency, significant constipation, and hypotension, and potentially considerable drug interactions, Specially with other CNS depressants, which include alcohol; individuals really should be instructed to talk to a healthcare Skilled if any new indications or Unwanted effects occur.
Drink alcohol or use prescription or above-the-counter medicines that have alcohol. Making use of merchandise containing alcohol for the duration of cure with acetaminophen and codeine phosphate tablets may perhaps induce you to overdose and die.
Be certain you know how to acquire this medication and what other medicines you'll want to stay away from having with it. See also Drug Interactions area. Get clinical assist without delay if any of these incredibly significant Unwanted side effects come about: slow/shallow respiration, unconventional lightheadedness, read more extreme drowsiness/dizziness, issue waking up.
In A further research one 100 mg/kg subcutaneous dose of codeine administered to pregnant mice reportedly resulted in delayed ossification during the offspring.
“Health practitioner shopping” (browsing various prescribers to get supplemental prescriptions) is typical between individuals that abuse medications and those with substance use dysfunction. Preoccupation with achieving satisfactory suffering aid may be acceptable behavior within a client with inadequate ache Regulate.
Accidental ingestion of acetaminophen and codeine phosphate tablets, Particularly by click here kids, may lead to respiratory despair and Demise on account of an overdose of codeine.